Proyecto FOLTRA

Lo afirmamos en 2012 y lo confirman ahora

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Lo afirmamos en 2012 y lo confirman ahora

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Jueves 03 de Marzo de 2016 00:00

En 2012 publicamos un trabajo experimental en ratas, en el que demostrábamos que la administración de GH era capaz de revertir el daño producido por la sección del nervio ciático, uno de los nervios periféricos hasta entonces imposible de reparar. Bajo estas líneas figua el abstract del trabajo entonces publicado en Muscle and Nerve. 

 2012 Mar;45(3):385-92. doi: 10.1002/mus.22303.

Growth hormone treatment enhances the functional recovery of sciatic nerves after transection and repair.

Author information

  • 1Department of Physiology, School of Medicine, University of Santiago de Compostela, San Francisco 1, 15782 Santiago de Compostela, Spain.

Abstract

INTRODUCTION: 

Although nerves can spontaneously regenerate in the peripheral nervous system without treatment, functional recovery is generally poor, and thus there is a need for strategies to improve nerve regeneration.

METHODS: 

The left sciatic nerve of adult rats was transected and immediately repaired by epineurial sutures. Rats were then assigned to one of two experimental groups treated with either growth hormone (GH) or saline for 8 weeks. Sciatic nerve regeneration was estimated by histological evaluation, nerve conduction tests, and rotarod and treadmill performance.

RESULTS: 

GH-treated rats showed increased cellularity at the lesion site together with more abundant immunoreactive axons and Schwann cells. Compound muscle action potential (CMAP) amplitude was also higher in these animals, and CMAP latency was significantly lower. Treadmill performance increased in rats receiving GH.

CONCLUSION: 

GH enhanced the functional recovery of the damaged nerves, thus supporting the use of GH treatment, alone or combined with other therapeutic approaches, in promoting nerve repair.

 

Como muchas veces se afirma que "vendemos humo", aquí está una muestra de que nadie, hasta ahora, ha rebatido ninguna de nuestras publicaciones que, desde hace ya muchos años, fueron en su día "rompedoras" del conocimiento existente. En este caso se trata de una publicación muy reciente, febrero de 2016, de neurólogos, neurocirujanos y cirujanos plásticos del Hospital Johns Hopkins de Baltimore (USA), una de las más acreditadas instituciones hospitalarias y científicas de Estados Unidos y, por ende, del mundo. Fíjense en el abstract del trabajo que publican:

 2016 Feb 11. [Epub ahead of print]

Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy Following Peripheral Nerve Injury.

Author information

  • 1Department of Neurology, Johns Hopkins (Hoke) Department of Medicine, Johns Hopkins (Salvatori) Curtis National Hand Center, Baltimore, MD (Higgins, Means) Department of Plastic and Reconstructive Surgery for the rest.

Abstract

BACKGROUND: 

Therapies to improve outcomes following peripheral nerve injury are lacking. Prolonged denervation of muscle and Schwann cells (SCs) contributes to poor outcomes. In this study, we assess the effects of growth hormone (GH) therapy on axonal regeneration, SC and muscle maintenance, and end-organ reinnervation in rats.

METHODS: 

Male Sprague-Dawley rats underwent sciatic nerve transection-and-repair and femoral nerve transection-without-repair and received either daily subcutaneous GH (0.4 mg/day) or no treatment (N=8 per group). At 5 weeks, we assessed axonal regeneration within the sciatic nerve, muscle atrophy within the gastrocnemius muscle, motor endplate reinnervation within the soleus muscle, and SC proliferation within the denervated distal femoral nerve.

RESULT: 

GH-treated animals demonstrated greater percent increase in body mass (12.2 1.8 vs. 8.5 1.5, p=0.0044), greater number of regenerating myelinated axons (13876 2036 vs. 8645 3279, p=0.0018) and G-ratio (0.64 0.11 vs. 0.51 0.06, p=0.01), greater percent reinnervation of motor endplates (75.8 8.7 vs. 38.2 22.6, p=0.0008), and greater muscle myofibril cross-sectional area (731.8 157 µm vs. 545.2 144.3 µm, p=0.027).

CONCLUSIONS: 

In male rats, GH therapy accelerates axonal regeneration, reduces muscle atrophy and promotes muscle reinnervation. GH therapy may also maintain proliferating SCs in the setting of prolonged denervation. These findings suggest potential for improved outcomes with GH therapy following peripheral nerve injuries.

 

 

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